|
Mutation Information
|
Mutation Site
|
Q381E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E1 |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
K02718.1
|
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
24236186
|
|
Disease
|
High grade squamous intraepithelial lesion;
Low grade squamous intraepithelial lesion;
Cervical carcinoma
|
|
Published Year
|
2013 |
|
Journal
|
PloS one |
|
Title
|
Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing. |
|
Author
|
Kukimoto I,Maehama T,Sekizuka T,Ogasawara Y,Kondo K,Kusumoto-Matsuo R,Mori S,Ishii Y,Takeuchi T,Yamaji T,Takeuchi F,Hanada K,Kuroda M |
|
Evidence
|
In transient replication assays, a novel E1 mutant found in ICC, E1 Q381E, showed reduced ability to support HPV16 origin-dependent replication.
|
|
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HPV Mutation Detail Information