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Mutation Information
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Mutation Site
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Q369H |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gag |
Literature Information
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PubMed PMID
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31622432
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Published Year
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2019 |
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Journal
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PloS one |
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Title
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Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study. |
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Author
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Dicker I,Zhang S,Ray N,Beno BR,Regueiro-Ren A,Joshi S,Cockett M,Krystal M,Lataillade M |
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Evidence
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Interestingly, one subject (# 22) with baseline R286K/V370M and BL FC of 1.6 acquired the Q369Q/H mixture on dosing, displayed a reduced susceptibility at Day 11 compared to baseline (FC = 12) and exhibited a virologic response of -0.93 log10 RNA.
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HIV Mutation Detail Information