HIV Mutation Detail Information

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Mutation Information

Mutation Site	Q369H
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag
Genotype/Subtype	B
Relevant Drug	PIs

Literature Information

PubMed PMID	27090171
Published Year	2016
Journal	Antimicrobial agents and chemotherapy
Title	Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Author	Nowicka-Sans B,Protack T,Lin Z,Li Z,Zhang S,Sun Y,Samanta H,Terry B,Liu Z,Chen Y,Sin N,Sit SY,Swidorski JJ,Chen J,Venables BL,Healy M,Meanwell NA,Cockett M,Hanumegowda U,Regueiro-Ren A,Krystal M,Dicker IB
Evidence	BMS-955176 also exhibits potent antiviral activity toward key Gag polymorphisms, with EC50s of <5 nM against V362I, Q369H, V370A/M, and T371A/Δ viruses.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation