|
Mutation Information
|
Mutation Site
|
Q280H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp120 |
|
Relevant Drug
|
acyclovir;tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
26132818
|
|
Published Year
|
2015 |
|
Journal
|
PloS one |
|
Title
|
The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications. |
|
Author
|
Gordts SC,Férir G,D'huys T,Petrova MI,Lebeer S,Snoeck R,Andrei G,Schols D |
|
Evidence
|
To identify mechanisms of LA resistance, we generated in vitro a mutant HIV-1 NL4.3LAresistant virus, which acquired seven mutations in the HIV-1 envelope glycoproteins: S160N, V170N, Q280H and R389T in gp120 and K77Q, N113D and H132Y in gp41.
|
|
|
HIV Mutation Detail Information