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HIV Mutation Detail Information

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Mutation Information
Mutation Site Q214L
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 32960169
Published Year 2020
Journal eLife
Title Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence While substitutions in IN had no measurable effect on Gag (Pr55) expression, modest effects on Gag processing in cells was visible for several missense mutant viruses including H12N, N18I, K34A, Y99A, K103E, W108R, F185K, Q214L/Q216L, L242A, V260E, as well as the DeltaIN mutant (Figure 2A).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation