|
Mutation Information
|
Mutation Site
|
Q14H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Combined Mutation
|
e6.Q14H+e6.H78Y+e6.L83V |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Sweden |
Literature Information
|
PubMed PMID
|
16519914
|
|
Published Year
|
2006 |
|
Journal
|
Virology |
|
Title
|
HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6. |
|
Author
|
Lichtig H,Algrisi M,Botzer LE,Abadi T,Verbitzky Y,Jackman A,Tommasino M,Zehbe I,Sherman L |
|
Evidence
|
Reduced activity in inhibition of p53 Arg transactivation was also displayed by V6 (Q14H/H78Y/L83V) and V7 (R48W).
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HPV Mutation Detail Information