|
Mutation Information
|
Mutation Site
|
Q148R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Combined Mutation
|
in.S230N+in.Q148R+in.S147G+in.E138K+in.L74M+in.T66I |
|
Relevant Drug
|
elvitegravir (EVG) |
Literature Information
|
PubMed PMID
|
32601157
|
|
Published Year
|
2020 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
HIV-1 Integrase Inhibitors That Are Active against Drug-Resistant Integrase Mutants. |
|
Author
|
Smith SJ,Zhao XZ,Passos DO,Lyumkis D,Burke TR Jr,Hughes SH |
|
Evidence
|
Both were superior to DTG, as evidenced by the data obtained with the IN mutant T66I/L74M/E138K/S147G/Q148R/S230N, which was selected by CAB using an EVG-resistant lab strain.
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HIV Mutation Detail Information