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Mutation Information
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Mutation Site
|
Q148R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
INSTIs |
Literature Information
|
PubMed PMID
|
31591964
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
eLife |
|
Title
|
Epistasis and entrenchment of drug resistance in HIV-1 subtype B. |
|
Author
|
Biswas A,Haldane A,Arnold E,Levy RM |
|
Evidence
|
The INSTI-selected resistance mutation Q148R in integrase, for example, is present in only about 5% of the patient population (in our dataset), but the mutation is entrenched in more than 85% of these sequences which have the mutation.
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HIV Mutation Detail Information