HIV Mutation Detail Information

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Mutation Information
Mutation Site Q148K
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Combined Mutation in.G140S+in.Q148K
Genotype/Subtype CRF63_02A1
Relevant Drug raltegravir (RAL)
Country Russia
Literature Information
PubMed PMID 31024744
Disease HIV infection/AIDS
Published Year 2019
Journal Acta naturae
Title Consensus Integrase of a New HIV-1 Genetic Variant CRF63_02A1.
Author Agapkina YY,Pustovarova MA,Korolev SP,Zyryanova DP,Ivlev VV,Totmenin AV,Gashnikova NM,Gottikh MB
Evidence It was also found that the drug resistance mutations Q148K/G140S and G118R/E138K significantly reduce the catalytic activity of IN_CRF and its sensitivity to the strand transfer inhibitor raltegravir.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation