HIV Mutation Detail Information

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Mutation Information

Mutation Site	Q148K
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	UK

Literature Information

PubMed PMID	30409215
Clinical information	Yes
Disease	HIV infection/AIDS
Published Year	2018
Journal	AIDS research and therapy
Title	Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay.
Author	Silver N,Paynter M,McAllister G,Atchley M,Sayir C,Short J,Winner D,Alouani DJ,Sharkey FH,Bergefall K,Templeton K,Carrington D,Quiñones-Mateu ME
Evidence	Most of the minority mutations in viruses from both groups of naive patients were observed in the RT, e.g., M41L, E44D, A62V, K65R, D67N, D67G, V75I, L100I, K103N, K103R, V188I, M184I, L210W, K219Q, Y318F, etc., although a number of minority mutations associated with resistance to PI (L10F, V11I, M46I/L, I50V, F53L, Q58E, T74S) or INSTI (L74I/M, E92G, E138K, S147G, G163R, Q148K) were also identified (Fig. 6).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation