|
Mutation Information
|
Mutation Site
|
Q148H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Combined Mutation
|
in.Q148H+in.G140S |
|
Relevant Drug
|
INSTIs |
Literature Information
|
PubMed PMID
|
33649107
|
|
Published Year
|
2021 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes. |
|
Author
|
White KL,Osman N,Cuadra-Foy E,Brenner BG,Shivakumar D,Campigotto F,Tsiang M,Morganelli PA,Novikov N,Lazerwith SE,Jin H,Niedziela-Majka A |
|
Evidence
|
BIC also had a longer t1/2 and maintained longer antiviral activity after drug washout than DTG with the clinically relevant resistance IN mutant G140S+Q148H.
|
|
|
HIV Mutation Detail Information