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Mutation Information
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Mutation Site
|
Q148H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Combined Mutation
|
in.Q148H+in.G140S |
|
Relevant Drug
|
INSTIs |
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Country
|
italy |
Literature Information
|
PubMed PMID
|
32450199
|
|
Disease
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HIV infection/AIDS
|
|
Published Year
|
2020 |
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Journal
|
International journal of antimicrobial agents |
|
Title
|
Susceptibility to HIV-1 integrase strand transfer inhibitors (INSTIs) in highly treatment-experienced patients who failed an INSTI-based regimen. |
|
Author
|
Santoro MM,Fornabaio C,Malena M,Galli L,Poli A,Menozzi M,Zazzi M,White KL,Castagna A,PRESTIGIO Study Group. |
|
Evidence
|
The primary INSTI resistance substitutions E138A/K, G140S, Y143C/H/R, Q148H and N155H were detected in 14 of 22 samples and were associated with resistance to one or more INSTIs, with G140S+Q148H present in 11 of 22 samples.
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HIV Mutation Detail Information