|
Mutation Information
|
Mutation Site
|
Q148H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
Literature Information
|
PubMed PMID
|
32001525
|
|
Published Year
|
2020 |
|
Journal
|
Science (New York, N.Y.) |
|
Title
|
Structural basis of second-generation HIV integrase inhibitor action and viral resistance. |
|
Author
|
Cook NJ,Li W,Berta D,Badaoui M,Ballandras-Colas A,Nans A,Kotecha A,Rosta E,Engelman AN,Cherepanov P |
|
Evidence
|
Q148H/G140S amino acid substitutions in IN that pervade clinical INSTI failure perturb optimal magnesium ion coordination in the enzyme active site.
|
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HIV Mutation Detail Information