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Mutation Information
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Mutation Site
|
Q148H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
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Genotype/Subtype
|
B |
|
Relevant Drug
|
INSTIs |
Literature Information
|
PubMed PMID
|
31591964
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
eLife |
|
Title
|
Epistasis and entrenchment of drug resistance in HIV-1 subtype B. |
|
Author
|
Biswas A,Haldane A,Arnold E,Levy RM |
|
Evidence
|
The mutations Q148R and Q148H for example, reduce susceptibilities to the IN strand transfer inhibitors (INSTIs) raltegravir (RAL) and elvitegravir (EVG) by 40-100 fold and 5-10 fold, respectively.
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HIV Mutation Detail Information