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Mutation Information
|
Mutation Site
|
Q148H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
INSTIs |
Literature Information
|
PubMed PMID
|
30568974
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
Open forum infectious diseases |
|
Title
|
Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir. |
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Author
|
George JM,Kuriakose SS,Dee N,Stoll P,Lalani T,Dewar R,Khan MA,Rehman MT,Grossman Z,Maldarelli F,Pau AK |
|
Evidence
|
In November 2014, a PhenoSense Integrase GT assay detected DRMs to NRTI, NNRTI, PI, and the INSTI-associated mutations E138T, G140S, and Q148H.
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|
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HIV Mutation Detail Information