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Mutation Information
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Mutation Site
|
Q146P |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
|
Country
|
US |
Literature Information
|
PubMed PMID
|
31617907
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
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Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance. |
|
Author
|
Tzou PL,Rhee SY,Descamps D,Clutter DS,Hare B,Mor O,Grude M,Parkin N,Jordan MR,Bertagnolio S,Schapiro JM,Harrigan PR,Geretti AM,Marcelin AG,Shafer RW,WHO HIVResNet Working Groups. |
|
Evidence
|
Two of the eight polymorphic mutations (A49P and G163K) and 14 of the 23 very rare mutations (L74F, E92V, Y143A/G/K, P145S, Q146I/L/P, V151A/L, S153Y and N155S/T) also had a regression coefficient ≥0.5 log10.
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HIV Mutation Detail Information