HIV Mutation Detail Information

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Mutation Information

Mutation Site	Q146P
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	18687142
Published Year	2008
Journal	Retrovirology
Title	Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors.
Author	Rhee SY,Liu TF,Kiuchi M,Zioni R,Gifford RJ,Holmes SP,Shafer RW
Evidence	Among the CCD mutations shown to directly reduce raltegravir or elvitegravir susceptibility - H51Y, T66I, E92Q, F121Y, G140S, Y143C/H/R, Q146P, S147G, Q148H/R/K, S153Y, N155H/S, and E157Q - only positions 153 and 157 are polymorphic (prevalence >= 0.5%) with S153A and E157Q each present in 1% of sequences (Figures 1).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation