HBV Mutation Detail Information

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Mutation Information
Mutation Site Q101H
Mutation Type Amino acid level
Gene/Protein/Region Type S
Literature Information
PubMed PMID 20412171
Disease HBV infection
Published Year 2010
Journal Vox sanguinis
Title Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes.
Author Scheiblauer H,El-Nageh M,Diaz S,Nick S,Zeichhardt H,Grunert HP,Prince A
Evidence There was 20-fold reduced sensitivity with mutant T131I (#1010), 13- to 120-fold reduced sensitivity with mutant Q101H (#1039), and mutant S143L (#1015) revealed a marked 500- to >1000-fold sensitivity reduction in two EIAs which would have been negative if it had not been for the high HBsAg concentration in the sample (>8000 IU/ml).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation