Mutation Information
Mutation Site
|
Q101H |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Literature Information
PubMed PMID
|
20412171
|
Disease
|
HBV infection
|
Published Year
|
2010 |
Journal
|
Vox sanguinis |
Title
|
Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes. |
Author
|
Scheiblauer H,El-Nageh M,Diaz S,Nick S,Zeichhardt H,Grunert HP,Prince A |
Evidence
|
There was 20-fold reduced sensitivity with mutant T131I (#1010), 13- to 120-fold reduced sensitivity with mutant Q101H (#1039), and mutant S143L (#1015) revealed a marked 500- to >1000-fold sensitivity reduction in two EIAs which would have been negative if it had not been for the high HBsAg concentration in the sample (>8000 IU/ml).
|
|
|