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Mutation Information
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Mutation Site
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P90A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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CA |
Literature Information
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PubMed PMID
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32187548
|
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Published Year
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2020 |
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Journal
|
Cell reports |
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Title
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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core. |
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Author
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Selyutina A,Persaud M,Simons LM,Bulnes-Ramos A,Buffone C,Martinez-Lopez A,Scoca V,Di Nunzio F,Hiatt J,Marson A,Krogan NJ,Hultquist JF,Diaz-Griffero F |
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Evidence
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We also found that the binding of TRIM5alphahu to mutant P90A HIV-1 cores was 5- to 6-fold higher than that of wild-type HIV-1 cores (Figure 3A) in the absence of CsA.
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HIV Mutation Detail Information