|
Mutation Information
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Mutation Site
|
P6A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Tax |
Literature Information
|
PubMed PMID
|
11070166
|
|
Published Year
|
2000 |
|
Journal
|
Immunity |
|
Title
|
Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling. |
|
Author
|
Baker BM,Gagnon SJ,Biddison WE,Wiley DC |
|
Evidence
|
The structure of the A6 alphabetaTCR/HTLV-1 Tax-peptide/MHC I complex with proline 6 of Tax substituted with alanine (P6A), an antagonist, is nearly identical to the structure with wild-type Tax agonist.
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HTLV1 Mutation Detail Information