HIV Mutation Detail Information

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Mutation Information
Mutation Site P63C
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Genotype/Subtype B
Viral Reference K03455.1
Immune Escape Y
Country Canada
Literature Information
PubMed PMID 30048246
Disease HIV infection/AIDS
Published Year 2018
Journal AIDS (London, England)
Title Extensive host immune adaptation in a concentrated North American HIV epidemic.
Author Brumme ZL,Kinloch NN,Sanche S,Wong A,Martin E,Cobarrubias KD,Sandstrom P,Levett PN,Harrigan PR,Joy JB
Evidence Strikingly, the Saskatchewan HIV consensus sequence differed from that in the rest of Canada/USA at 9 Pol codons: E35D, P63C and I93L in Protease, and I135T, S162C, P272A, E297A, Q334L, and E399D in reverse transcriptase (Fig. ​(Fig.1c),1c), a remarkable observation given Pol's relative conservation and the long-term stability of the North American [8] and global (http://www.hiv.lanl.gov/) subtype B Pol consensus sequences.

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Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation