HIV Mutation Detail Information

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Mutation Information

Mutation Site	P453S
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag

Literature Information

PubMed PMID	31622432
Published Year	2019
Journal	PloS one
Title	Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study.
Author	Dicker I,Zhang S,Ray N,Beno BR,Regueiro-Ren A,Joshi S,Cockett M,Krystal M,Lataillade M
Evidence	Additional emergent substitutions included two changes in the SP2/p6 cleavage site: P453S, co-selected at 100% with A364V after passage 2, and S495N that emerged by day 78 but did not increase beyond 20-30% over the course of 5 passages (45 days).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation