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Mutation Information
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Mutation Site
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P40T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpu |
Literature Information
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PubMed PMID
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31234536
|
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Published Year
|
2019 |
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Journal
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Medical sciences (Basel, Switzerland) |
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Title
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In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts. |
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Author
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Sneha P,Shah U,Balaji S |
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Evidence
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The single point mutations in tetherin at positions L23Y, L24T, and P40T, and triple mutations at {L22S, F44Y, L37I} and {L23T, L37T, T45I}, while single point mutations in Vpu at positions A19H and W23Y and triplet of mutations at {V10K, A11L, A19T}, {V14T, I18T, I26S}, and {A11T, V14L, A15T} have revealed no polar contacts with minimal hydrophobic interactions between Vpu and tetherin, resulting in reduced binding affinity.
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HIV Mutation Detail Information