HPV Mutation Detail Information

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Mutation Information
Mutation Site P38A
Mutation Type Amino acid level
Gene/Protein/Region Type E6
Genotype/Subtype HPV8
Literature Information
PubMed PMID 30875834
Published Year 2019
Journal Cells
Title The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene.
Author Taute S,Böhnke P,Sprissler J,Buchholz S,Hufbauer M,Akgül B,Steger G
Evidence The P40A, V70A and L63A/W65A mutants in HPV5E6, which correspond to P38A, L61A/W63A and V68A in HPV8E6, respectively, lost completely their activity to induce the degradation of Bak, but still partially inhibited apoptosis [52], indicating that other activities than targeting Bak may contribute to HV8E6-mediated inhibition of UV-induced apoptosis.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation