Mutation Information
Mutation Site
|
P373S |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Env |
Relevant Drug
|
PIs |
Literature Information
PubMed PMID
|
27090171
|
Published Year
|
2016 |
Journal
|
Antimicrobial agents and chemotherapy |
Title
|
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage. |
Author
|
Nowicka-Sans B,Protack T,Lin Z,Li Z,Zhang S,Sun Y,Samanta H,Terry B,Liu Z,Chen Y,Sin N,Sit SY,Swidorski JJ,Chen J,Venables BL,Healy M,Meanwell NA,Cockett M,Hanumegowda U,Regueiro-Ren A,Krystal M,Dicker IB |
Evidence
|
P373S was subsequently introduced into this proviral clone (NLRepRlucP373S = wild type [WT]), since P373S is the most common variation at 373 within SP1 in subtype B.
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