Mutation Information
Mutation Site
|
P308T |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Gp120 |
Literature Information
PubMed PMID
|
21356539
|
Published Year
|
2011 |
Journal
|
Virology |
Title
|
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41. |
Author
|
Anastassopoulou CG,Ketas TJ,Depetris RS,Thomas AM,Klasse PJ,Moore JP |
Evidence
|
Of note is that the resistance-relevant proline at residue 308 was absent from the reversion isolates, and although a change arose at this position, it was not to the dominant parental histidine, but to a new amino acid, threonine (i.e., P308T).
|
|
|