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Mutation Information
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Mutation Site
|
P225H |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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NNRTIs |
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Country
|
South Africa |
Literature Information
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PubMed PMID
|
31143879
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
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Journal
|
EClinicalMedicine |
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Title
|
Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis. |
|
Author
|
Chimukangara B,Lessells RJ,Rhee SY,Giandhari J,Kharsany ABM,Naidoo K,Lewis L,Cawood C,Khanyile D,Ayalew KA,Diallo K,Samuel R,Hunt G,Vandormael A,Stray-Pedersen B,Gordon M,Makadzange T,Kiepiela P,Ramjee G,Ledwaba J,Kalimashe M,Morris L,Parikh UM,Mellors JW,Shafer RW,Katzenstein D,Moodley P,Gupta RK,Pillay D,Abdool Karim SS,de Oliveira T |
|
Evidence
|
Other common NNRTI-resistance mutations included V106AM (n = 47), Y181C (n = 34), K101EP (n = 29) and G190ASE (n = 27). Overall, 77/374 (20.6%) had more than one NNRTI DRM, most commonly K103N + P225H (n = 16) and K103N + V106M (n = 12).
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HIV Mutation Detail Information