HIV Mutation Detail Information

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Mutation Information
Mutation Site P225H
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug NNRTIs
Country Africa
Literature Information
PubMed PMID 30513108
Disease HIV infection/AIDS
Published Year 2018
Journal PLoS medicine
Title Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial.
Author Kityo C,Szubert AJ,Siika A,Heyderman R,Bwakura-Dangarembizi M,Lugemwa A,Mwaringa S,Griffiths A,Nkanya I,Kabahenda S,Wachira S,Musoro G,Rajapakse C,Etyang T,Abach J,Spyer MJ,Wavamunno P,Nyondo-Mipando L,Chidziva E,Nathoo K,Klein N,Hakim J,Gibb DM,Walker AS,Pett SL,REALITY trial team.
Evidence The NRTI mutation K219E/Q (p = 0.004) and the NNRTI mutations K101E/P (p = 0.03) and P225H (p = 0.007) were less common in raltegravir-intensified ART, with no evidence of differences for other mutations (p > 0.1, S8 Fig).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation