Mutation Information
Mutation Site
|
P217L |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Country
|
Italy |
Literature Information
PubMed PMID
|
23796863
|
Disease
|
HBV infection
|
Published Year
|
2013 |
Journal
|
The Journal of infection |
Title
|
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen. |
Author
|
Cento V,Van Hemert F,Neumann-Fraune M,Mirabelli C,Di Maio VC,Salpini R,Bertoli A,Micheli V,Gubertini G,Romano S,Visca M,De Sanctis GM,Berkhout B,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Ceccherini-Silberstein F,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V |
Evidence
|
Furthermore, the HBsAg-mutation sP217L, silent in RT, significantly correlated with M204V/I-related virological-breakthrough and increased HBsAg-quantification in cell-lysate.
|
|
|