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Mutation Information
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Mutation Site
|
P203Q |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
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Viral Reference
|
X02763.1;
X65259.1 |
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Country
|
Italy |
Literature Information
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PubMed PMID
|
28152517
|
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Disease
|
Chronic hepatitis B
|
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Published Year
|
2017 |
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Journal
|
Oncotarget |
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Title
|
Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro. |
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Author
|
Salpini R,Surdo M,Warner N,Cortese MF,Colledge D,Soppe S,Bellocchi MC,Armenia D,Carioti L,Continenza F,Di Carlo D,Saccomandi P,Mirabelli C,Pollicita M,Longo R,Romano S,Cappiello G,Spanò A,Trimoulet P,Fleury H,Vecchiet J,Iapadre N,Barlattani A,Bertoli A,Mari T,Pasquazzi C,Missale G,Sarrecchia C,Orecchini E,Michienzi A,Andreoni M,Francioso S,Angelico M,Verheyen J,Ceccherini-Silberstein F,Locarnini S,Perno CF,Svicher V |
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Evidence
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Two HBsAg mutations significantly correlated with HCC: P203Q (17.4% [4/23] in HCC vs 1.0% [1/105] in non-HCC, P=0.004); S210R (34.8% [8/23] in HCC vs 3.8% [4/105] in non-HCC, P <0.001); P203Q+S210R (17.4% [4/23] in HCC vs 0% [0/110] in non-HCC, P=0.001).
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HBV Mutation Detail Information