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Mutation Information
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Mutation Site
|
P178Q |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
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Genotype/Subtype
|
E |
|
Country
|
Côte d'Ivoire |
Literature Information
|
PubMed PMID
|
30257068
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2019 |
|
Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
|
Title
|
Effect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa. |
|
Author
|
Boyd A,Moh R,Maylin S,Abdou Chekaraou M,Mahjoub N,Gabillard D,Anglaret X,Eholié SP,Danel C,Delaugerre C,Zoulim F,Lacombe K,ANRS 12240 VarBVA study. |
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Evidence
|
At ART initiation, median HBV-DNA was 7.27 log10 copies/mL (IQR = 5.26-8.33) and qHBsAg 4.08 log10 IU/mL (IQR = 3.49-4.61). Twelve S-gene MUPIQHs were identified among 21 patients (28.8%): sS140L (n = 4), sD144A (n = 1), sS167L (n = 2), sS174N (n = 6), sP178Q (n = 2), sG185L (n = 2), sW191L (n = 2), sP203Q/R (n = 2), sS204N/I/R/K/T/G (n = 7), sN207T (n = 2), sF212C (n = 1) and sV224A/Y (n = 7).
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HBV Mutation Detail Information