EBV Mutation Detail Information

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Mutation Information

Mutation Site	P178A
Mutation Type	Amino acid level
Gene/Protein/Region Type	BILF1

Literature Information

PubMed PMID	30647152
Published Year	2019
Journal	mBio
Title	Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation.
Author	Fares S,Spiess K,Olesen ETB,Zuo J,Jackson S,Kledal TN,Wills MR,Rosenkilde MM
Evidence	Three mutants, Δ17-N-term, K86A, and P178A mutants, showed even higher activity compared to wt EBV-BILF1 at low DNA concentrations (Fig. 3C, ,D,D, and andF),F), whereas two mutants, E90A and R169A mutants, showed reduced signaling activity compared to wt EBV-BILF1 (Fig. 3D and andE).E).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation