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Mutation Information
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Mutation Site
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P12T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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S |
Literature Information
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PubMed PMID
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32882910
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Published Year
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2020 |
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Journal
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Viruses |
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Title
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Expression Level of Small Envelope Protein in Addition to Sequence Divergence inside Its Major Hydrophilic Region Contributes to More Efficient Surface Antigen Secretion by Hepatitis B Virus Subgenotype D2 than Subgenotype A2. |
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Author
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Wang Q,Fu S,Zhang J,Yuan Q,Li J,Xia N,Wen YM,Wang Y,Tong S |
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Evidence
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For residues covered by chi3.2, the P12T mutation of DpreS/AS was more effective than K11R or A13V in reducing intracellular HBsAg while increasing extracellular HBsAg to promote HBsAg secretion (Figure 10A-C, top panel).
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HBV Mutation Detail Information