|
Mutation Information
|
Mutation Site
|
P127T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
24700252
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2014 |
|
Journal
|
Infection |
|
Title
|
HBV whole-genome mutation profile in HIV-1/HBV coinfected patients in a long-term follow-up study. |
|
Author
|
Taffon S,Genovese D,Blasi M,Pierotti P,Degli Esposti A,Catone S,Chionne P,Pulimanti B,Candido A,Dettori S,Tosti ME,Argentini C,Mazzotta F,Rapicetta M |
|
Evidence
|
Known mutants Y100C, P127T and P120A associated to Y134H and S143T and new S mutants, which may potentially affect HBsAg expression and secretion and anti-HBs binding, were detected in baseline sera persisting up to the end of 9 years follow-up.
|
|
|
HBV Mutation Detail Information