|
Mutation Information
|
Mutation Site
|
P127S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
X02496;
M23138;
AY721605 |
|
Relevant Drug
|
entecavir (ETV);tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
22313146
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis
|
|
Published Year
|
2012 |
|
Journal
|
Transfusion |
|
Title
|
Reactivation of hepatitis B virus with mutated hepatitis B surface antigen in a liver transplant recipient receiving a graft from an antibody to hepatitis B surface antigen- and antibody to hepatitis B core antigen-positive donor. |
|
Author
|
Blaich A,Manz M,Dumoulin A,Schüttler CG,Hirsch HH,Gerlich WH,Frei R |
|
Evidence
|
In the plasma sample taken on June 21, 2010, after 4 months of entecavir therapy, the mutant Q129R was no longer detected, but P127S predominated.
|
|
|
HBV Mutation Detail Information