|
Mutation Information
|
Mutation Site
|
P127L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Amino acid_Mutation
|
C379A |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
HM358335.1
|
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
27381922
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2017 |
|
Journal
|
Journal of medical virology |
|
Title
|
HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg. |
|
Author
|
Sadeghi A,Shirvani-Dastgerdi E,Tacke F,Yagmur E,Poortahmasebi V,Poorebrahim M,Mohraz M,Hajabdolbaghi M,Rasoolinejad M,Abbasian L,Jafari R,Fakhari Z,Norouzi M,Ebrahimian A,Geravand B,Alavian SM,Jazayeri SM |
|
Evidence
|
We generated a series of expression constructs of variant HBsAg with "a" determinant amino acid substitutions including P127L, P127T, S136Y, and P127T + S136Y using site-directed mutagenesis.
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|
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HBV Mutation Detail Information