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Mutation Information
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Mutation Site
|
P125A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gag |
Literature Information
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PubMed PMID
|
30327442
|
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Published Year
|
2018 |
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Journal
|
mBio |
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Title
|
Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation. |
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Author
|
Novikova M,Adams LJ,Fontana J,Gres AT,Balasubramaniam M,Winkler DC,Kudchodkar SB,Soheilian F,Sarafianos SG,Steven AC,Freed EO |
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Evidence
|
While mutations P123A and P125A were relatively well tolerated, mutation of P122 and I124 significantly impaired virus release, caused Gag processing defects, and abolished infectivity.
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HIV Mutation Detail Information