|
Mutation Information
|
Mutation Site
|
P123A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
Literature Information
|
PubMed PMID
|
30327442
|
|
Published Year
|
2018 |
|
Journal
|
mBio |
|
Title
|
Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation. |
|
Author
|
Novikova M,Adams LJ,Fontana J,Gres AT,Balasubramaniam M,Winkler DC,Kudchodkar SB,Soheilian F,Sarafianos SG,Steven AC,Freed EO |
|
Evidence
|
While mutations P123A and P125A were relatively well tolerated, mutation of P122 and I124 significantly impaired virus release, caused Gag processing defects, and abolished infectivity.
|
|
|
HIV Mutation Detail Information