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Mutation Information
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Mutation Site
|
N88S |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
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atazanavir (ATV);nelfinavir (NFV);indinavir (IDV);saquinavir (SQV) |
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Country
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USA |
Literature Information
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PubMed PMID
|
32371875
|
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Disease
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HIV infection/AIDS
|
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Published Year
|
2020 |
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Journal
|
Scientific reports |
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Title
|
HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-naïve blood donors in China. |
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Author
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Zhao J,Lv X,Chang L,Ji H,Harris BJ,Zhang L,Jiang X,Guo F,Hackett J Jr,Yin P,Cloherty GA,Rodgers MA,Wang L |
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Evidence
|
The PI major DRMs included M46L, M46I and N88S. M46I/L caused PLLR to many INSTIs among HIV-1 positive individuals, while N88S could result in HLR to Atazanavir (ATV) and NFV, LLR to Indinavir (IDV) and Saquinavir (SQV).
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HIV Mutation Detail Information