Mutation Information
Mutation Site
|
N88D |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Genotype/Subtype
|
D |
Relevant Drug
|
NRTIs |
Literature Information
PubMed PMID
|
30648124
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2019 |
Journal
|
Open forum infectious diseases |
Title
|
Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance. |
Author
|
Ahmed N,Flavell S,Ferns B,Frampton D,Edwards SG,Miller RF,Grant P,Nastouli E,Gupta RK |
Evidence
|
At that time, resistance testing showed NRTI (M184V, T69D, T215S, D67N, K219Q), NNRTI (Y181C, Y188L, H221Y) and PI (L10I, D30N, K20T, L33F, K43T, N88D) resistance, with PI resistance to nelfinavir. Integrase polymorphisms (17N, 256E, 112V, 113V, 201I, 234I) were detected.
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