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Mutation Information
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Mutation Site
|
N88D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
B;F1 |
|
Country
|
Brazilian |
Literature Information
|
PubMed PMID
|
18992847
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2009 |
|
Journal
|
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
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Title
|
Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. |
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Author
|
Dumans AT,Barreto CC,Santos AF,Arruda M,Sousa TM,Machado ES,Sabino EC,Brindeiro RM,Tanuri A,Duarte AJ,Soares MA |
|
Evidence
|
Conversely, mutations L10V, K20M, L33F, M36I, G73S, and N88D were significantly more prevalent in subtype B viruses from treated patients compared to untreated individuals (p = 0.002, p = 0.005, p = 0.02, p < 0.0001, p = 0.0005, and p = 0.02, respectively), but this was not true for subtype F1.
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HIV Mutation Detail Information