HIV Mutation Detail Information

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Mutation Information

Mutation Site	N88D
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Genotype/Subtype	B
Relevant Drug	PIs

Literature Information

PubMed PMID	17500586
Disease	HIV infection/AIDS
Published Year	2007
Journal	PLoS computational biology
Title	HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
Author	Rhee SY,Liu TF,Holmes SP,Shafer RW
Evidence	Patterns of protease covariation were dominated by the clustering of nelfinavir-associated mutations (D30N and N88D), two main groups of protease inhibitor (PI)-resistance mutations associated either with V82A or L90M, and a tight cluster of mutations associated with decreased susceptibility to amprenavir and the most recently approved PI darunavir.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation