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HIV Mutation Detail Information

> N83D Search Result


Mutation Information
Mutation Site N83D
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Literature Information
PubMed PMID 31920003
Published Year 2020
Journal The FEBS journal
Title Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
Author Kneller DW,Agniswamy J,Harrison RW,Weber IT
Evidence In the protease hinge region, the N83D mutation eliminates a hydrogen bond connecting the hinge and core of the protease and increases disorder compared to highly resistant mutants PR with 17 mutations and PR with 20 mutations with similar hinge mutations.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation