Mutation Information
Mutation Site
|
N74D |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
CA |
Literature Information
PubMed PMID
|
32709741
|
Published Year
|
2020 |
Journal
|
Proceedings of the National Academy of Sciences of the United States of America |
Title
|
Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. |
Author
|
Elsner C,Ponnurangam A,Kazmierski J,Zillinger T,Jansen J,Todt D,Döhner K,Xu S,Ducroux A,Kriedemann N,Malassa A,Larsen PK,Hartmann G,Barchet W,Steinmann E,Kalinke U,Sodeik B,Goffinet C |
Evidence
|
Strikingly, HIV-1 (CA N74D) and HIV-1 (CA P90A) failed to trigger a detectable elevation of IFIT1 and MX2 mRNA expression in PM1 T cells (SI Appendix, Fig. S6C).
|
|
|