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Mutation Information
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Mutation Site
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N74D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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CA |
Literature Information
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PubMed PMID
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32665593
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Published Year
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2020 |
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Journal
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Nature communications |
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Title
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HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. |
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Author
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Francis AC,Marin M,Singh PK,Achuthan V,Prellberg MJ,Palermino-Rowland K,Lan S,Tedbury PR,Sarafianos SG,Engelman AN,Melikyan GB |
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Evidence
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Accordingly, CPSF6 interaction-defective N74D9 and A77V35 CA mutant viruses were defective for SPAD integration targeting in HEK293T cells, as well as in primary MDMs and CD4+ T cells (Fig. 8b, c, e, f and Supplementary Fig. 6a, b).
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HIV Mutation Detail Information