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Mutation Information
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Mutation Site
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N74D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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CA |
Literature Information
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PubMed PMID
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32553106
|
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Published Year
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2020 |
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Journal
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eLife |
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Title
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MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface. |
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Author
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Miles RJ,Kerridge C,Hilditch L,Monit C,Jacques DA,Towers GJ |
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Evidence
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The HIV-1 capsid is the key determinant of MxB sensitivity and cofactor binding defective HIV-1 capsid mutants P90A (defective for cyclophilin A and Nup358 recruitment) and N74D (defective for CPSF6 recruitment) have reduced dependency on nuclear transport associated cofactors, altered integration targeting preferences and are not restricted by MxB expression.
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HIV Mutation Detail Information