Mutation Information
Mutation Site
|
N637K |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Gp41 |
Literature Information
PubMed PMID
|
27992602
|
Published Year
|
2016 |
Journal
|
PLoS pathogens |
Title
|
Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer. |
Author
|
Khasnis MD,Halkidis K,Bhardwaj A,Root MJ |
Evidence
|
The multiphasic titration curve for EnvQ552R/N637K suggested that its N-HR coiled coil adopts the asymmetric conformation observed in the crystal structure of the mutant TOH.
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