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Mutation Information
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Mutation Site
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N58S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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E6 |
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Genotype/Subtype
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HPV16 |
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Country
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Sweden |
Literature Information
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PubMed PMID
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16519914
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Published Year
|
2006 |
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Journal
|
Virology |
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Title
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HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6. |
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Author
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Lichtig H,Algrisi M,Botzer LE,Abadi T,Verbitzky Y,Jackman A,Tommasino M,Zehbe I,Sherman L |
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Evidence
|
The data presented herein show that mutations represented in V1 (K10G), V3 (N58S), V4 (R10G/L83V), V7 (R48W), and V9 (R8Q) reduced binding to E6BP (0.29 to 0.79 of the E6 PT activity).
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HPV Mutation Detail Information