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Mutation Information
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Mutation Site
|
N55H |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpu |
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Country
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USA |
Literature Information
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PubMed PMID
|
24465210
|
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Disease
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HIV infection/AIDS
|
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Published Year
|
2014 |
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Journal
|
PLoS pathogens |
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Title
|
Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals. |
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Author
|
Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ |
|
Evidence
|
Interestingly, mutations occurring at the DSGNES beta-TrCP binding site that occurred between the two phosphorylated serines, N55H (n = 2) and E56G (n = 1), were highly specific and deleterious for anti-tetherin activity, but were functional for CD4 downregulation.
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HIV Mutation Detail Information