HIV Mutation Detail Information

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Mutation Information

Mutation Site	N519S
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	azvudine (FNC);lamivudine (LAM)

Literature Information

PubMed PMID	25144636
Published Year	2014
Journal	PloS one
Title	Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.
Author	Wang RR,Yang QH,Luo RH,Peng YM,Dai SX,Zhang XJ,Chen H,Cui XQ,Liu YJ,Huang JF,Chang JB,Zheng YT
Evidence	The frequencies of N519S located in the RNase H domain were also observed from 6.06% to 70.83% in P-5 to P-21 variants of FNC (Table 4).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation